What conditions does Cefaclor ER treat? No serious sequelae have been reported. Rarely, hypersensitivity symptoms may persist for several months. Susceptible indicates that antimicrobial is likely to inhibit growth of the pathogen if the antimicrobial compound reaches the concentrations at the site of infection necessary to inhibit growth of the pathogen. A report of Intermediate indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of drug can be used. This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of Resistant indicates that the antimicrobial is not likely to inhibit growth of the pathogen if the antimicrobial compound reaches the concentrations usually achievable at the infection site; other therapy should be selected.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Clinical and Laboratory Standards Institute CLSI. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard - Tenth Edition. CLSI document M07-A10, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Penicillin-VK while you are pregnant. Penicillin-VK is found in breast milk. If you are or will be breast-feeding while you use Penicillin-VK, check with your doctor. Discuss any possible risks to your baby.
Cefaclor works best if it is taken at the same times each day. This should not be used if you have certain medical conditions. Extended release tablets: Do not chew, crush, or split; administer with or within 1 hour of food. Hypersensitivity to cefaclor and other cephalosporins. Cefaclor Capsules, USP are a semisynthetic cephalosporin antibiotic for oral administration. It is chemically designated as 3-chloro-7-D-2-phenylglycinamido-3-cephem-4-carboxylic acid monohydrate.
Probenecid: May increase the serum concentration of Cephalosporins. To clear up your infection completely, take Penicillin-VK for the full course of treatment. Keep taking it even if you feel better in a few days. Other effects considered related to therapy included eosinophilia 1 in 50 patients genital pruritus, moniliasis or vaginitis about 1 in 50 patients and, rarely, thrombocytopenia or reversible interstitial nephritis. If you have any questions about Penicillin-VK, please talk with your doctor, pharmacist, or other health care provider.
This may not be a complete list of all interactions that may occur. Ask your health care provider if cefaclor may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Peritoneal dialysis: Administer 50% of the recommended dose based on indication. Other drugs may interact with cefaclor, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Store the liquid medicine in the refrigerator, do not freeze. Throw away any unused liquid after 14 days. What happens if I miss a dose? If you miss a dose of cefaclor capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Acute bacterial exacerbations of chronic bronchitis extended-release tablets only: Treatment of acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae excluding beta-lactamase-negative, ampicillin-resistant strains only Moraxella catarrhalis, or Streptococcus pneumoniae. Approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours, the greater portion being excreted within the first 2 hours. Pennsylvania 19087, USA, 2015. Ask your health care provider any questions you may have about how to use Penicillin-VK. Standard Cefaclor powder should provide the following range of MIC values noted in Table 2. For the diffusion technique using the 30 mcg disk the criteria in Table 2 should be achieved. Otitis media capsules and oral suspension only: Treatment of otitis media caused by S. pneumoniae, H. influenzae, staphylococci, and S. pyogenes. Careful observation of the patient is essential.
Cefaclor MR tablets are engraved “TA4220”. Symptoms may include diarrhea, nausea, stomach pain, and vomiting. How often did hospital staff describe possible side effects in a way you could understand? Teriflunomide: May increase the serum concentration of OAT3 Substrates. Phenazopyridine can dye your urine and tears orange-red. Resistance to cefaclor is primarily through hydrolysis of ß-lactamases alteration of penicillin-binding proteins PBPs and decreased permeability. Pseudomonas spp. Dermatologic side effects have included pruritus, maculopapular rash, rash, and urticaria. IF AN ALLERGIC REACTION TO Cefaclor OCCURS, DISCONTINUE THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. If your symptoms do not improve or if they become worse, check with your doctor.
Confusion, erythema multiforme, genital pruritus, hepatic dysfunction including cholestasis, hemolytic anemia, reversible hyperactivity, hypertonia, and reversible interstitial nephritis. Do not crush, chew, or break an extended-release tablet. Accidental injury, anorexia, anxiety, arthralgia, asthma, bronchitis, chest pain, chills, congestive heart failure, conjunctivitis, constipation, dizziness, dysmenorrhea, dyspepsia, dysuria, ear pain, edema, fever, flatulence, flu syndrome, gastritis, infection, insomnia, leukorrhea, lung disorder, maculopapular rash, malaise, menstrual disorder, myalgia, nausea and vomiting, neck pain, nervousness, nocturia, otitis media, pain, palpitation, peripheral edema, rash, respiratory disorder, sinusitis, somnolence, surgical procedure, sweating, tremor, urticaria, vomiting. What happens if I miss a dose? Cefaclor extended-release tablets USP, 500 mg based on the anhydrous are available as film-coated, oval-shaped, unscored, dark blue tablets, debossed with “93” on one side and “1087” on the other side. They are available in bottles of 100. Vitamin K Antagonists eg, warfarin: Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists. Cefaclor should be administered for at least 10 days when treating beta-hemolytic streptococcal infections. This procedure uses paper disks impregnated with 30 mcg Cefaclor to test the susceptibility of microorganisms to Cefaclor. Positive direct Coombs', false-positive urinary glucose test using cupric sulfate Benedict's solution, Clinitest, Fehling's solution. Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure as required. Multum Information Services, Inc.
Prescribing cefaclor extended-release tablets USP in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. The safety and effectiveness of Cefaclor MR have not been established. Secondary bacterial infections of acute bronchitis due to Haemophilus influenzae excluding ß-lactamase-negative, ampicillin-resistant strains Moraxella catarrhalis, or Streptococcus pneumoniae. See above NOTE. Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. The zone size provides an estimate of the susceptibility of bacteria to antimicrobial compounds. Penicillin allergy: Use with caution in patients with a history of penicillin allergy. Elderly subjects with normal renal function do not require dosage adjustment. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. BEFORE THERAPY WITH CEFACLOR EXTENDED-RELEASE TABLETS IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFACLOR, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. IF THIS PRODUCT IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-SENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. IF AN ALLERGIC REACTION TO CEFACLOR EXTENDED-RELEASE TABLETS OCCURS, DISCONTINUE THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Acute Bacterial Exacerbations of Chronic Bronchitis due to H. influenzae non-ß-lactamase-producing strains only. Moraxella catarrhalis including ß-lactamase-producing strains or Streptococcus pneumoniae See INDICATIONS AND USAGE. Pharyngitis, tonsillitis, skin and skin structure infections: 375mg twice daily. These studies have revealed no harm to the fetus due to cefaclor. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, cefaclor extended-release tablets should be used during pregnancy only if clearly needed.
This information should not be used to decide whether or not to take Penicillin-VK or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Penicillin-VK. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Penicillin-VK. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Penicillin-VK. This medication can cause you to have unusual results with certain medical tests. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Protect the patient's airway and support ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patient's vital signs, blood gases, serum electrolytes, etc. Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which, in many cases, is more effective than emesis or lavage; consider charcoal instead of or in addition to gastric emptying. Repeated doses of charcoal over time may hasten elimination of some drugs that have been absorbed. Safeguard the patient's airway when employing gastric emptying or charcoal. Clinical and Laboratory Standards Institute CLSI.
If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated. Cephalosporins as a class have been associated with toxic nephropathy, reversible interstitial nephritis, and renal dysfunction. Goumas P, Naxakis S, Bassaris C, Skoutelis A "Comparative efficacy and tolerability of clarithromycin and cefaclor in the treatment of outpatients with acute maxillary sinusitis. No overall differences in safety or effectiveness were observed between these subjects and younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. The effect of cefaclor on labor and delivery is unknown. This antibiotic only treats bacterial infections. Hypersensitivity: Anaphylactic reactions have occurred. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefaclor will not treat a viral infection such as the flu or a common cold. For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same times every day. Gastrointestinal side effects have included diarrhea, nausea, vomiting, and abdominal pain. Table 2 should be achieved. Renal impairment: Use with caution in patients with renal impairment. This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases. To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefaclor and other antibacterial drugs, cefaclor should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. WITH A HISTORY OF PENICILLIN ALLERGY. Small amounts of Cefaclor have been detected in mother's milk following administration of single 500 mg doses.
Cefaclor Capsules, USP 500 mg: opaque purple and gray hard gelatin capsules imprinted with “West-ward 986” in bottles of 15 and bottles of 100. This is given by injection into a vein as directed by your doctor, usually every 8 or 12 hours. The dosage is based on your medical condition and response to treatment. Check with your pharmacist about how to dispose of unused medicine. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody stools or urine; fever, chills, or persistent sore throat; severe or persistent diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal irritation or itching; worsening of skin lesions. The absorption of cefaclor extended-release is enhanced when it is administered with food. Small amounts of cefaclor have been detected in mother's milk following administration of single 500 mg doses. Slight elevations in BUN or serum creatinine less than 1 in 500 or abnormal urinalysis less than 1 in 200. Do not miss any doses. If you miss a dose of Penicillin-VK, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Avoid using antacids within 1 hour before or after taking cefaclor. Cephalosporins as a class have been associated with elevated LDH, hepatic dysfunction, and cholestasis. Duration: 10 to 14 days. Longer courses of therapy, sometimes 3 to 4 weeks, may be required for refractory or recurrent cases. Adverse events were not observed in animal reproduction studies. An increased risk of teratogenic effects has not been observed following maternal use of cefaclor.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients. Store at room temperature at 68 to 77 degrees F 20 to 25 degrees C in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep cefaclor out of the reach of children and pets. Phenylketonuria patients - Cefaclor contains phenylalanine. General management consists of supportive therapy. Patient may experience diarrhea. Have patient report immediately to prescriber bruising, bleeding, seizures, chills, pharyngitis, severe loss of strength and energy, severe dizziness, passing out, burning or numbness feeling, urinary retention, change in amount of urine passed, vaginitis, or signs of Clostridium difficile C. diff-associated diarrhea abdominal pain or cramps, severe diarrhea or watery stools, or bloody stools HCAHPS. Cefaclor is a semi-synthetic cephalosporin antibiotic. Cefaclor extended-release tablets have been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. IF AN ALLERGIC REACTION TO CEFACLOR OCCURS, DISCONTINUE THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. Your pharmacist can provide more information about cefaclor.
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Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. This procedure uses paper disks impregnated with 30-mcg cefaclor to test the susceptibility of microorganisms to cefaclor. Quenzer RW, Davis RL, Neidhart MM "Prospective randomized study comparing the efficacy and safety of ciprofloxacin with cefaclor in the treatment of patients with purulent bronchitis. The plasma half-life in healthy subjects is independent of dosage form and averages approximately 1 hour. Symptoms may include diarrhea; nausea; vomiting.
As has also been reported with other β-lactam antibiotics, transient lymphocytosis, leukopenia, and, rarely, hemolytic anemia, aplastic anemia, agranulocytosis, and reversible neutropenia of possible clinical significance. Take Penicillin-VK by mouth. Penicillin-VK is best absorbed when taken on an empty stomach 1 hour before or 2 hours after meals but may be taken with food. Red No. 40, strawberry flavor.
Tachia, Taichung 43769, TAIWAN. Cefaclor is moderately dialyzable 20% to 30% reduction in half-life. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose?
Note: Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Cefaclor is generally effective in the eradication of streptococci from the nasopharynx; however, substantial data establishing the efficacy of cefaclor in the subsequent prevention of rheumatic fever are not available at present. NOTE: The extent of absorption AUC of cefaclor from cefaclor immediate-release capsules is unaffected by food intake; however, when cefaclor immediate-release capsules are taken with food, the C max is decreased. Genitourinary side effects have included genital pruritus and vaginitis in less than 1% of patients.